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2015 ; 15
(61
): 137-50
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Perihepatic lymphadenopathy in children with chronic viral hepatitis
#MMPMID26676184
Schreiber-Dietrich D
; Pohl M
; Cui XW
; Braden B
; Dietrich CF
; Chiorean L
J Ultrason
2015[Jun]; 15
(61
): 137-50
PMID26676184
show ga
OBJECTIVE: To assess whether lymph node enlargement in the hepatoduodenal
ligament occurs in children with chronic viral hepatitis B and C in comparison to
healthy controls. SUBJECT AND METHODS: In 49 patients with chronic viral
hepatitis (38 with chronic hepatitis B, 11 with chronic hepatitis C, 31 male, 18
female; age range 1 to 17 years), and in 51 healthy controls (25 male, 26 female;
age range 4 to 16 years), the total perihepatic lymph node volume was assessed
using transabdominal ultrasonography as previously described in adult patients.
RESULTS: Adequate visualization of the liver hilum was achieved in 46/49 (94%)
pediatric patients with chronic viral hepatitis and in 46/51 (90%) pediatric
healthy controls. In patients with adequate liver hilum visualization, enlarged
perihepatic lymph nodes (longitudinal diameter >14 mm) were detected in 32/46
(70%) patients with chronic viral hepatitis and in 5/46 (11%) healthy controls.
The total perihepatic lymph nodes volume [mean ± SD] was 1.0 ± 1.2 mL (0.1-5.4
mL) in patients with chronic viral hepatitis and 0.1 ± 0.1 mL (0.0-0.4 mL) in
healthy controls (p < 0.05). A maximal lymph node diameter >14 mm identified
patients with chronic viral hepatitis with 70% sensitivity and 89% specificity.
CONCLUSION: Transabdominal ultrasound can detect lymph nodes within the
hepatoduodenal ligament not only in adults but also in children. Paediatric
patients with chronic viral hepatitis have significantly enlarged perihepatic
lymph nodes compared to controls. Therefore, sonographic assessment of
perihepatic lymphadenopathy might be a non-invasive diagnostic tool to screen
paediatric patients for chronic viral hepatitis.