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10.1038/s41467-017-01738-3 http://scihub22266oqcxt.onion/10.1038/s41467-017-01738-3 C5691060!5691060 !29146905     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29146905 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29146905 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 1574 Nephropedia Template TP {{tp|p=29146905 |t=2017. Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1 |pdf=|usr=}}{{29146905 }} gab.com Text Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29146905 #FOAvip Pericytes adhere to the abluminal surface of endothelial tubules and are required for the formation of stable vascular networks. Defective endothelial cell-pericyte interactions are frequently observed in diseases characterized by compromised vascular integrity such as diabetic retinopathy. Many functional properties of pericytes and their exact role in the regulation of angiogenic blood vessel growth remain elusive. Here we show that pericytes promote endothelial sprouting in the postnatal retinal vasculature. Using genetic and pharmacological approaches, we show that the expression of vascular endothelial growth factor receptor 1 (VEGFR1) by pericytes spatially restricts VEGF signalling. Angiogenic defects caused by pericyte depletion are phenocopied by intraocular injection of VEGF-A or pericyte-specific inactivation of the murine gene encoding VEGFR1. Our findings establish that pericytes promote endothelial sprouting, which results in the loss of side branches and the enlargement of vessels when pericyte function is impaired or lost. Twit Text FOAVip Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29146905 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29146905 #FOAvip English Wikipedia <ref>{{Cite pmid|29146905 }}</ref> Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1 #MMPMID29146905 Eilken HM ; Diéguez-Hurtado R ; Schmidt I ; Nakayama M ; Jeong HW ; Arf H ; Adams S ; Ferrara N ; Adams RH Nat Commun 2017[Nov]; 8 (1 ): 1574 PMID29146905 show ga Pericytes adhere to the abluminal surface of endothelial tubules and are required for the formation of stable vascular networks. Defective endothelial cell-pericyte interactions are frequently observed in diseases characterized by compromised vascular integrity such as diabetic retinopathy. Many functional properties of pericytes and their exact role in the regulation of angiogenic blood vessel growth remain elusive. Here we show that pericytes promote endothelial sprouting in the postnatal retinal vasculature. Using genetic and pharmacological approaches, we show that the expression of vascular endothelial growth factor receptor 1 (VEGFR1) by pericytes spatially restricts VEGF signalling. Angiogenic defects caused by pericyte depletion are phenocopied by intraocular injection of VEGF-A or pericyte-specific inactivation of the murine gene encoding VEGFR1. Our findings establish that pericytes promote endothelial sprouting, which results in the loss of side branches and the enlargement of vessels when pericyte function is impaired or lost. |Animals [MESH] |Capillaries/cytology/growth & development [MESH] |Cell Line [MESH] |Diphtheria Toxin/toxicity [MESH] |Endothelial Cells/cytology/*metabolism [MESH] |Eye/*blood supply [MESH] |Heparin-binding EGF-like Growth Factor/metabolism [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Neovascularization, Physiologic/*physiology [MESH] |Pericytes/cytology/*metabolism [MESH] |Receptor, Platelet-Derived Growth Factor beta/genetics [MESH] |Retina/metabolism [MESH] |Signal Transduction [MESH] |Vascular Endothelial Growth Factor A/*metabolism [MESH]Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1 (epmc).pdf DeepDyve Pubget Overpricing