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10.2147/IJN.S105274

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C4892861!4892861 !27313454
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suck abstract from ncbi


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pmid27313454
      Int+J+Nanomedicine 2016 ; 11 (ä): 2397-406
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  • Pericyte-targeting drug delivery and tissue engineering #MMPMID27313454
  • Kang E ; Shin JW
  • Int J Nanomedicine 2016[]; 11 (ä): 2397-406 PMID27313454 show ga
  • Pericytes are contractile mural cells that wrap around the endothelial cells of capillaries and venules. Depending on the triggers by cellular signals, pericytes have specific functionality in tumor microenvironments, properties of potent stem cells, and plasticity in cellular pathology. These features of pericytes can be activated for the promotion or reduction of angiogenesis. Frontier studies have exploited pericyte-targeting drug delivery, using pericyte-specific peptides, small molecules, and DNA in tumor therapy. Moreover, the communication between pericytes and endothelial cells has been applied to the induction of vessel neoformation in tissue engineering. Pericytes may prove to be a novel target for tumor therapy and tissue engineering. The present paper specifically reviews pericyte-specific drug delivery and tissue engineering, allowing insight into the emerging research targeting pericytes.
  • |Animals [MESH]
  • |Antineoplastic Agents/pharmacology [MESH]
  • |Capillaries/cytology [MESH]
  • |Drug Delivery Systems/*methods [MESH]
  • |Humans [MESH]
  • |Neovascularization, Pathologic/drug therapy/pathology [MESH]
  • |Peptides/administration & dosage/pharmacology [MESH]
  • |Pericytes/*drug effects/metabolism [MESH]
  • |Signal Transduction [MESH]
  • |Stem Cells/cytology [MESH]
  • |Tissue Engineering/*methods [MESH]
  • |Tumor Microenvironment [MESH]


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