Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27313454
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Pericyte-targeting drug delivery and tissue engineering
#MMPMID27313454
Kang E
; Shin JW
Int J Nanomedicine
2016[]; 11
(?): 2397-406
PMID27313454
show ga
Pericytes are contractile mural cells that wrap around the endothelial cells of
capillaries and venules. Depending on the triggers by cellular signals, pericytes
have specific functionality in tumor microenvironments, properties of potent stem
cells, and plasticity in cellular pathology. These features of pericytes can be
activated for the promotion or reduction of angiogenesis. Frontier studies have
exploited pericyte-targeting drug delivery, using pericyte-specific peptides,
small molecules, and DNA in tumor therapy. Moreover, the communication between
pericytes and endothelial cells has been applied to the induction of vessel
neoformation in tissue engineering. Pericytes may prove to be a novel target for
tumor therapy and tissue engineering. The present paper specifically reviews
pericyte-specific drug delivery and tissue engineering, allowing insight into the
emerging research targeting pericytes.
free
free
free
