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10.1073/pnas.1608384113 http://scihub22266oqcxt.onion/10.1073/pnas.1608384113 C5035870!5035870 !27608497     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27608497 &cmd=llinks): Failed to open stream: HTTP request failed! 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Pericyte-fibroblast transition promotes tumor growth and metastasis |pdf=|usr=}}{{27608497 }} gab.com Text Pericyte-fibroblast transition promotes tumor growth and metastasis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27608497 #FOAvip Vascular pericytes, an important cellular component in the tumor microenvironment, are often associated with tumor vasculatures, and their functions in cancer invasion and metastasis are poorly understood. Here we show that PDGF-BB induces pericyte-fibroblast transition (PFT), which significantly contributes to tumor invasion and metastasis. Gain- and loss-of-function experiments demonstrate that PDGF-BB-PDGFR? signaling promotes PFT both in vitro and in in vivo tumors. Genome-wide expression analysis indicates that PDGF-BB-activated pericytes acquire mesenchymal progenitor features. Pharmacological inhibition and genetic deletion of PDGFR? ablate the PDGF-BB-induced PFT. Genetic tracing of pericytes with two independent mouse strains, TN-AP-CreERT2:R26R-tdTomato and NG2-CreERT2:R26R-tdTomato, shows that PFT cells gain stromal fibroblast and myofibroblast markers in tumors. Importantly, coimplantation of PFT cells with less-invasive tumor cells in mice markedly promotes tumor dissemination and invasion, leading to an increased number of circulating tumor cells and metastasis. Our findings reveal a mechanism of vascular pericytes in PDGF-BB-promoted cancer invasion and metastasis by inducing PFT, and thus targeting PFT may offer a new treatment option of cancer metastasis. Twit Text FOAVip Pericyte-fibroblast transition promotes tumor growth and metastasis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27608497 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27608497 #FOAvip English Wikipedia <ref>{{Cite pmid|27608497 }}</ref> Pericyte-fibroblast transition promotes tumor growth and metastasis #MMPMID27608497 Hosaka K ; Yang Y ; Seki T ; Fischer C ; Dubey O ; Fredlund E ; Hartman J ; Religa P ; Morikawa H ; Ishii Y ; Sasahara M ; Larsson O ; Cossu G ; Cao R ; Lim S ; Cao Y Proc Natl Acad Sci U S A 2016[Sep]; 113 (38 ): E5618-27 PMID27608497 show ga Vascular pericytes, an important cellular component in the tumor microenvironment, are often associated with tumor vasculatures, and their functions in cancer invasion and metastasis are poorly understood. Here we show that PDGF-BB induces pericyte-fibroblast transition (PFT), which significantly contributes to tumor invasion and metastasis. Gain- and loss-of-function experiments demonstrate that PDGF-BB-PDGFR? signaling promotes PFT both in vitro and in in vivo tumors. Genome-wide expression analysis indicates that PDGF-BB-activated pericytes acquire mesenchymal progenitor features. Pharmacological inhibition and genetic deletion of PDGFR? ablate the PDGF-BB-induced PFT. Genetic tracing of pericytes with two independent mouse strains, TN-AP-CreERT2:R26R-tdTomato and NG2-CreERT2:R26R-tdTomato, shows that PFT cells gain stromal fibroblast and myofibroblast markers in tumors. Importantly, coimplantation of PFT cells with less-invasive tumor cells in mice markedly promotes tumor dissemination and invasion, leading to an increased number of circulating tumor cells and metastasis. Our findings reveal a mechanism of vascular pericytes in PDGF-BB-promoted cancer invasion and metastasis by inducing PFT, and thus targeting PFT may offer a new treatment option of cancer metastasis. |Animals [MESH] |Becaplermin [MESH] |Carcinoma, Renal Cell/*genetics/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Fibroblasts/metabolism/pathology [MESH] |Humans [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Neoplasm Metastasis [MESH] |Neovascularization, Pathologic/genetics/pathology [MESH] |Pericytes/*metabolism/pathology [MESH] |Proto-Oncogene Proteins c-sis/*genetics/metabolism [MESH] |Receptor, Platelet-Derived Growth Factor beta/antagonists & inhibitors/*genetics [MESH] |Tumor Microenvironment/genetics [MESH]Pericyte-fibroblast transition promotes tumor growth and metastasis (epmc).pdf DeepDyve Pubget Overpricing