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2016 ; 129
(4
): 673-80
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Pellicle formation in the malaria parasite
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Kono M
; Heincke D
; Wilcke L
; Wong TW
; Bruns C
; Herrmann S
; Spielmann T
; Gilberger TW
J Cell Sci
2016[Feb]; 129
(4
): 673-80
PMID26763910
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The intraerythrocytic developmental cycle of Plasmodium falciparum is completed
with the release of up to 32 invasive daughter cells, the merozoites, into the
blood stream. Before release, the final step of merozoite development is the
assembly of the cortical pellicle, a multi-layered membrane structure. This
unique apicomplexan feature includes the inner membrane complex (IMC) and the
parasite's plasma membrane. A dynamic ring structure, referred to as the basal
complex, is part of the IMC and helps to divide organelles and abscises in the
maturing daughter cells. Here, we analyze the dynamics of the basal complex of P.
falciparum. We report on a novel transmembrane protein of the basal complex
termed BTP1, which is specific to the genus Plasmodium. It colocalizes with the
known basal complex marker protein MORN1 and shows distinct dynamics as well as
localization when compared to other IMC proteins during schizogony. Using a
parasite plasma membrane marker cell line, we correlate dynamics of the basal
complex with the acquisition of the maternal membrane. We show that plasma
membrane invagination and IMC propagation are interlinked during the final steps
of cell division.
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