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2015 ; 31
(1
): 68-70
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Pediatric lupus: varied haematological picture and presentation
#MMPMID25548448
Thakur N
; Chandra J
; Dhingra B
; Singh V
Indian J Hematol Blood Transfus
2015[Mar]; 31
(1
): 68-70
PMID25548448
show ga
Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease
characterized by periods of increased disease activity caused by inflammation of
blood vessels and connective tissue. Pediatric patients with SLE have a more
severe clinical course when compared with adults. Patients commonly present with
rash, fever, and arthritis, although the presentation may be unpredictable.
Hematological findings are more predominant in children than adults. Thirty-nine
percent of children with SLE will develop hematological abnormalities, one of the
American Rheumatic Association criteria for classifying the disease. In our case
series we found varied hematological picture and presentation. We present here
four case reports of SLE cases with interesting hematological features. Our first
case is a 13 month old female child who was initially diagnosed as Evans syndrome
and 2 years later diagnosed as SLE. Second case is a 3 year old male child who
had SLE with warm antibody AIHA. Third case is a 6 year old female child who
presented with AIHA and was diagnosed with SLE 6 years later. Fourth case is a
6 year old female child diagnosed as SLE with aplastic anemia. Hematological
findings should be carefully assessed and treated in order to decrease disease
related morbidity.