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2018 ; 57
(7
): 987-991
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Pazopanib-induced Endothelial Injury with Podocyte Changes
#MMPMID29269661
Maruyama K
; Nakagawa N
; Suzuki A
; Kabara M
; Matsuki M
; Shindo M
; Ogawa Y
; Hasebe N
Intern Med
2018[Apr]; 57
(7
): 987-991
PMID29269661
show ga
Pazopanib has been reported to induce proteinuria; however, no pathological
findings have been reported. We herein report the case of a 31-year-old man with
rhabdomyosarcoma treated with pazopanib who developed nephrotic syndrome. A renal
biopsy revealed endothelial injury with podocyte changes. Based on the biopsy
findings, we diagnosed the patient with nephrotic syndrome caused by pazopanib.
Following the discontinuation of pazopanib, the patient's proteinuria gradually
decreased without any specific treatment. We should be careful when encountering
drug-induced proteinuria in patients taking pazopanib.