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10.2169/internalmedicine.9576-17

http://scihub22266oqcxt.onion/10.2169/internalmedicine.9576-17
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suck abstract from ncbi


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pmid29269661
      Intern+Med 2018 ; 57 (7 ): 987-991
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  • Pazopanib-induced Endothelial Injury with Podocyte Changes #MMPMID29269661
  • Maruyama K ; Nakagawa N ; Suzuki A ; Kabara M ; Matsuki M ; Shindo M ; Ogawa Y ; Hasebe N
  • Intern Med 2018[Apr]; 57 (7 ): 987-991 PMID29269661 show ga
  • Pazopanib has been reported to induce proteinuria; however, no pathological findings have been reported. We herein report the case of a 31-year-old man with rhabdomyosarcoma treated with pazopanib who developed nephrotic syndrome. A renal biopsy revealed endothelial injury with podocyte changes. Based on the biopsy findings, we diagnosed the patient with nephrotic syndrome caused by pazopanib. Following the discontinuation of pazopanib, the patient's proteinuria gradually decreased without any specific treatment. We should be careful when encountering drug-induced proteinuria in patients taking pazopanib.
  • |Adult [MESH]
  • |Humans [MESH]
  • |Indazoles [MESH]
  • |Male [MESH]
  • |Nephrotic Syndrome/*chemically induced/*diagnostic imaging/pathology/therapy [MESH]
  • |Podocytes/pathology [MESH]
  • |Proteinuria/*chemically induced/therapy [MESH]
  • |Pyrimidines/*adverse effects/*therapeutic use [MESH]
  • |Receptors, Vascular Endothelial Growth Factor/*therapeutic use [MESH]
  • |Rhabdomyosarcoma/*drug therapy [MESH]


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