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10.1083/jcb.201610048

http://scihub22266oqcxt.onion/10.1083/jcb.201610048
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C5350520!5350520 !28174204
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suck abstract from ncbi


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pmid28174204
      J+Cell+Biol 2017 ; 216 (3 ): 559-570
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  • Patterned cell and matrix dynamics in branching morphogenesis #MMPMID28174204
  • Wang S ; Sekiguchi R ; Daley WP ; Yamada KM
  • J Cell Biol 2017[Mar]; 216 (3 ): 559-570 PMID28174204 show ga
  • Many embryonic organs undergo branching morphogenesis to maximize their functional epithelial surface area. Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM). During branching morphogenesis, new branches form by "budding" or "clefting." Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs. Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation. New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
  • |Animals [MESH]
  • |Cell Differentiation/physiology [MESH]
  • |Cell Movement/physiology [MESH]
  • |Cell Proliferation/physiology [MESH]
  • |Epithelial Cells/physiology [MESH]
  • |Extracellular Matrix/*physiology [MESH]


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