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Patterned cell and matrix dynamics in branching morphogenesis
#MMPMID28174204
Wang S
; Sekiguchi R
; Daley WP
; Yamada KM
J Cell Biol
2017[Mar]; 216
(3
): 559-570
PMID28174204
show ga
Many embryonic organs undergo branching morphogenesis to maximize their
functional epithelial surface area. Branching morphogenesis requires the
coordinated interplay of multiple types of cells with the extracellular matrix
(ECM). During branching morphogenesis, new branches form by "budding" or
"clefting." Cell migration, proliferation, rearrangement, deformation, and ECM
dynamics have varied roles in driving budding versus clefting in different
organs. Elongation of the newly formed branch and final maturation of the tip
involve cellular mechanisms that include cell elongation, intercalation,
convergent extension, proliferation, and differentiation. New methodologies such
as high-resolution live imaging, tension sensors, and force-mapping techniques
are providing exciting new opportunities for future research into branching
morphogenesis.