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10.1126/science.aac9407 http://scihub22266oqcxt.onion/10.1126/science.aac9407 C4869713!4869713 !26494174     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26494174 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2015 ; 350 (6263 ): 985-90 Nephropedia Template TP {{tp|p=26494174 |t=2015. Patrolling monocytes control tumor metastasis to the lung |pdf=|usr=}}{{26494174 }} gab.com Text Patrolling monocytes control tumor metastasis to the lung JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=26494174 #FOAvip The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors is unknown. Here we show that PMo are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models. Nr4a1-deficient mice, which specifically lack PMo, showed increased lung metastasis in vivo. Transfer of Nr4a1-proficient PMo into Nr4a1-deficient mice prevented tumor invasion in the lung. PMo established early interactions with metastasizing tumor cells, scavenged tumor material from the lung vasculature, and promoted natural killer cell recruitment and activation. Thus, PMo contribute to cancer immunosurveillance and may be targets for cancer immunotherapy. Twit Text FOAVip Patrolling monocytes control tumor metastasis to the lung ????Science http://www.kidney.de/pget.php?&tw=1&pmid=26494174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26494174 #FOAvip English Wikipedia <ref>{{Cite pmid|26494174 }}</ref> Patrolling monocytes control tumor metastasis to the lung #MMPMID26494174 Hanna RN ; Cekic C ; Sag D ; Tacke R ; Thomas GD ; Nowyhed H ; Herrley E ; Rasquinha N ; McArdle S ; Wu R ; Peluso E ; Metzger D ; Ichinose H ; Shaked I ; Chodaczek G ; Biswas SK ; Hedrick CC Science 2015[Nov]; 350 (6263 ): 985-90 PMID26494174 show ga The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors is unknown. Here we show that PMo are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models. Nr4a1-deficient mice, which specifically lack PMo, showed increased lung metastasis in vivo. Transfer of Nr4a1-proficient PMo into Nr4a1-deficient mice prevented tumor invasion in the lung. PMo established early interactions with metastasizing tumor cells, scavenged tumor material from the lung vasculature, and promoted natural killer cell recruitment and activation. Thus, PMo contribute to cancer immunosurveillance and may be targets for cancer immunotherapy. |Animals [MESH] |Immunologic Surveillance/*immunology [MESH] |Immunotherapy/methods [MESH] |Killer Cells, Natural/immunology [MESH] |Lung Neoplasms/*immunology/*secondary/therapy [MESH] |Mice [MESH] |Mice, Mutant Strains [MESH] |Monocytes/*immunology [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Metastasis [MESH] |Neoplasms, Experimental/immunology/secondary [MESH]Patrolling monocytes control tumor metastasis to the lung (epmc).pdf DeepDyve Pubget Overpricing