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2016 ; 18
(11
): 1136-1142
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Patient safety in genomic medicine: an exploratory study
#MMPMID27011058
Korngiebel DM
; Fullerton SM
; Burke W
Genet Med
2016[Nov]; 18
(11
): 1136-1142
PMID27011058
show ga
PURPOSE: Concerns about patient safety and the potential for medical error are
largely unexplored for genetic testing, despite the expansion of test use. In
this preliminary qualitative study, we sought the views of genetics professionals
about error and patient safety concerns in genomic medicine and factors that
might mitigate them. METHODS: Twelve semistructured interviews with experienced
genetics professionals were conducted. Transcripts were analyzed using selective
coding for issues related to error definition, mitigation, and communication.
Additional thematic analysis captured themes across content categories. RESULTS:
Key informants suggested that the potential for adverse events exists in all
phases of genetic testing, from ordering to analysis, interpretation, and
follow-up. A perceived contributor was lack of physician knowledge about
genetics, resulting in errors in test ordering and interpretation. The
limitations and uncertainty inherent to rapidly evolving technology were also
seen as contributing factors. Strategies to prevent errors included physician
education, availability of genetic experts for consultation, and enhanced
communication such as improved test reports and electronic decision support.
CONCLUSION: Genetic testing poses concerns for patient safety due to errors and
the limitations of current tests. As genomic tests are integrated into medical
care, anticipating and addressing patient safety concerns identified by these key
informants will be crucial.Genet Med 18 11, 1136-1142.