Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.jmb.2014.07.004 http://scihub22266oqcxt.onion/10.1016/j.jmb.2014.07.004 C4135015!4135015 !25036288     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25036288 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Mol+Biol 2014 ; 426 (18 ): 3148-3165 Nephropedia Template TP {{tp|p=25036288 |t=2014. Pathways for virus assembly around nucleic acids |pdf=|usr=}}{{25036288 }} gab.com Text Pathways for virus assembly around nucleic acids JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25036288 #FOAvip Understanding the pathways by which viral capsid proteins assemble around their genomes could identify key intermediates as potential drug targets. In this work, we use computer simulations to characterize assembly over a wide range of capsid protein-protein interaction strengths and solution ionic strengths. We find that assembly pathways can be categorized into two classes, in which intermediates are either predominantly ordered or disordered. Our results suggest that estimating the protein-protein and the protein-genome binding affinities may be sufficient to predict which pathway occurs. Furthermore, the calculated phase diagrams suggest that knowledge of the dominant assembly pathway and its relationship to control parameters could identify optimal strategies to thwart or redirect assembly to block infection. Finally, analysis of simulation trajectories suggests that the two classes of assembly pathways can be distinguished in single-molecule fluorescence correlation spectroscopy or bulk time-resolved small-angle X-ray scattering experiments. Twit Text FOAVip Pathways for virus assembly around nucleic acids ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25036288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25036288 #FOAvip English Wikipedia <ref>{{Cite pmid|25036288 }}</ref> Pathways for virus assembly around nucleic acids #MMPMID25036288 Perlmutter JD ; Perkett MR ; Hagan MF J Mol Biol 2014[Sep]; 426 (18 ): 3148-3165 PMID25036288 show ga Understanding the pathways by which viral capsid proteins assemble around their genomes could identify key intermediates as potential drug targets. In this work, we use computer simulations to characterize assembly over a wide range of capsid protein-protein interaction strengths and solution ionic strengths. We find that assembly pathways can be categorized into two classes, in which intermediates are either predominantly ordered or disordered. Our results suggest that estimating the protein-protein and the protein-genome binding affinities may be sufficient to predict which pathway occurs. Furthermore, the calculated phase diagrams suggest that knowledge of the dominant assembly pathway and its relationship to control parameters could identify optimal strategies to thwart or redirect assembly to block infection. Finally, analysis of simulation trajectories suggests that the two classes of assembly pathways can be distinguished in single-molecule fluorescence correlation spectroscopy or bulk time-resolved small-angle X-ray scattering experiments. |*Algorithms [MESH] |*Models, Molecular [MESH] |*Virus Assembly [MESH] |Amino Acid Sequence [MESH] |Capsid Proteins/chemistry/*metabolism [MESH] |Capsid/*metabolism [MESH] |Computer Simulation [MESH] |Molecular Sequence Data [MESH] |Nucleic Acids/metabolism [MESH] |Protein Binding [MESH]Pathways for virus assembly around nucleic acids (epmc).pdf DeepDyve Pubget Overpricing