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2015 ; 3
(4
): 468-472
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Pathophysiology of microwave-induced traumatic brain injury
#MMPMID26171150
Igarashi Y
; Matsuda Y
; Fuse A
; Ishiwata T
; Naito Z
; Yokota H
Biomed Rep
2015[Jul]; 3
(4
): 468-472
PMID26171150
show ga
Microwave technology has been widely used in numerous applications; however,
excessive microwave exposure causes adverse effects, particularly in the brain.
The present study aimed to evaluate the change in the number of neural cells and
presence of apoptotic cells in rats for one month after exposure to excessive
microwave radiation. The rats were exposed to 3.0 kW of microwaves for 0.1 sec
and were sacrificed after 24 h (n=3), or 3 (n=3), 7 (n=3), 14 (n=3) or 28 days
(n=4) of exposure. The neural cells were counted in the motor cortex and
hippocampus [cornu ammonis 1 (CA1) and CA2] and the percentage of positive cells
stained with terminal deoxynucleotidyl transferase-mediated deoxyuridine
triphosphate nick-end labeling (TUNEL) were also measured, which detected
apoptotic cell death in the choroid plexus in the lateral ventricle, motor cortex
and hippocampus. In the CA1, the number of neural cells decreased significantly
by day 28 compared with that in the control (60.7 vs. 50.6, P=0.0358), but did
not decrease before day 28. There were no significant differences on any day in
the CA2 and the motor cortex. The number of cells showed a significant increase
on day 7 compared to the control in the choroid plexus (2.1±1.1 vs. 21.8±19.1%,
P=0.0318). There were no significant differences from the controls in the
percentage of TUNEL-positive cells in the motor cortex and hippocampus. The
effects of microwave exposure on the brain remain unclear; however,
microwave-induced neurotrauma shows the same pathological changes as blast
traumatic brain injury.