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2018 ; 22
(1
): 86-91
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Pathophysiology of keratinization
#MMPMID29731562
Deo PN
; Deshmukh R
J Oral Maxillofac Pathol
2018[Jan]; 22
(1
): 86-91
PMID29731562
show ga
Cytoskeleton of a cell is made up of microfilaments, microtubules and
intermediate filaments. Keratins are diverse proteins. These intermediate
filaments maintain the structural integrity of the keratinocytes. The word
keratin covers these intermediate filament-forming proteins within the
keratinocytes. They are expressed in a specific pattern and according to the
stage of cellular differentiation. They always occur in pairs. Mutations in the
genes which regulate the expression of keratin proteins are associated with a
number of disorders which show defects in both skin and mucosa. In addition,
there are a number of disorders which are seen because of abnormal
keratinization. These keratins and keratin-associated proteins have become
important markers in diagnostic pathology. This review article discusses the
classification, structure, functions, the stains used for the demonstration of
keratin and associated pathology. The review describes the physiology of
keratinization, pathology behind abnormal keratin formation and various keratin
disorders.