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10.3748/wjg.v13.i48.6458 http://scihub22266oqcxt.onion/10.3748/wjg.v13.i48.6458 C4611283!4611283 !18161914     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18161914 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18161914 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       World+J+Gastroenterol 2007 ; 13 (48 ): 6458-64 Nephropedia Template TP {{tp|p=18161914 |t=2007. Pathophysiology of increased intestinal permeability in obstructive jaundice |pdf=|usr=}}{{18161914 }} gab.com Text Pathophysiology of increased intestinal permeability in obstructive jaundice JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=18161914 #FOAvip Despite advances in preoperative evaluation and postoperative care, intervention, especially surgery, for relief of obstructive jaundice still carries high morbidity and mortality rates, mainly due to sepsis and renal dysfunction. The key event in the pathophysiology of obstructive jaundice-associated complications is endotoxemia of gut origin because of intestinal barrier failure. This breakage of the gut barrier in obstructive jaundice is multi-factorial, involving disruption of the immunologic, biological and mechanical barrier. Experimental and clinical studies have shown that obstructive jaundice results in increased intestinal permeability. The mechanisms implicated in this phenomenon remain unresolved, but growing research interest during the last decade has shed light in our knowledge in the field. This review summarizes the current concepts in the pathophysiology of obstructive jaundice-induced gut barrier dysfunction, analyzing pivotal factors, such as altered intestinal tight junctions expression, oxidative stress and imbalance of enterocyte proliferation and apoptosis. Clinicians handling patients with obstructive jaundice should not neglect protecting the intestinal barrier function before, during and after intervention for the relief of this condition, which may improve their patients' outcome. Twit Text FOAVip Pathophysiology of increased intestinal permeability in obstructive jaundice ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=18161914 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18161914 #FOAvip English Wikipedia <ref>{{Cite pmid|18161914 }}</ref> Pathophysiology of increased intestinal permeability in obstructive jaundice #MMPMID18161914 Assimakopoulos SF ; Scopa CD ; Vagianos CE World J Gastroenterol 2007[Dec]; 13 (48 ): 6458-64 PMID18161914 show ga Despite advances in preoperative evaluation and postoperative care, intervention, especially surgery, for relief of obstructive jaundice still carries high morbidity and mortality rates, mainly due to sepsis and renal dysfunction. The key event in the pathophysiology of obstructive jaundice-associated complications is endotoxemia of gut origin because of intestinal barrier failure. This breakage of the gut barrier in obstructive jaundice is multi-factorial, involving disruption of the immunologic, biological and mechanical barrier. Experimental and clinical studies have shown that obstructive jaundice results in increased intestinal permeability. The mechanisms implicated in this phenomenon remain unresolved, but growing research interest during the last decade has shed light in our knowledge in the field. This review summarizes the current concepts in the pathophysiology of obstructive jaundice-induced gut barrier dysfunction, analyzing pivotal factors, such as altered intestinal tight junctions expression, oxidative stress and imbalance of enterocyte proliferation and apoptosis. Clinicians handling patients with obstructive jaundice should not neglect protecting the intestinal barrier function before, during and after intervention for the relief of this condition, which may improve their patients' outcome. |Bile/physiology [MESH] |Cell Proliferation [MESH] |Enterocytes/physiology [MESH] |Humans [MESH] |Intestinal Absorption/*physiology [MESH] |Jaundice, Obstructive/pathology/*physiopathology [MESH] |Oxidative Stress/physiology [MESH]Pathophysiology of increased intestinal permeability in obstructive ja(epmc).pdf DeepDyve Pubget Overpricing