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2014 ; 46 Suppl 1
(0 1
): S11-21
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Pathophysiology and animal modeling of underactive bladder
#MMPMID25238890
Tyagi P
; Smith PP
; Kuchel GA
; de Groat WC
; Birder LA
; Chermansky CJ
; Adam RM
; Tse V
; Chancellor MB
; Yoshimura N
Int Urol Nephrol
2014[Sep]; 46 Suppl 1
(0 1
): S11-21
PMID25238890
show ga
While the symptomology of underactive bladder (UAB) may imply a primary
dysfunction of the detrusor muscle, insights into pathophysiology indicate that
both myogenic and neurogenic mechanisms need to be considered. Due to lack of
proper animal models, the current understanding of the UAB pathophysiology is
limited, and much of what is known about the clinical etiology of the condition
has been derived from epidemiological data. We hereby review current state of the
art in the understanding of the pathophysiology of and animal models used to
study the UAB.