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2017 ; 4
(ä): 120
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Pathophysiological Mechanisms in Sclerosing Skin Diseases
#MMPMID28868289
Eckes B
; Wang F
; Moinzadeh P
; Hunzelmann N
; Krieg T
Front Med (Lausanne)
2017[]; 4
(ä): 120
PMID28868289
show ga
Sclerosing skin diseases represent a large number of distinct disease entities,
which include systemic sclerosis, localized scleroderma, and scleredema
adultorum. These pathologies have a common clinical appearance and share
histological features. However, the specific interplay between cytokines and
growth factors, which activate different mesenchymal cell populations and
production of different extracellular matrix components, determines the
biomechanical properties of the skin and the clinical features of each disease. A
better understanding of the mechanisms underlying these events is prerequisite
for developing novel targeted therapeutic approaches.