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10.1016/j.brainres.2014.05.052 http://scihub22266oqcxt.onion/10.1016/j.brainres.2014.05.052 C4256948!4256948 !25108040     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25108040 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25108040 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Brain+Res 2014 ; 1584 (ä): 52-8 Nephropedia Template TP {{tp|p=25108040 |t=2014. Pathological stress granules in Alzheimer s disease |pdf=|usr=}}{{25108040 }} gab.com Text Pathological stress granules in Alzheimer s disease JO: Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=25108040 #FOAvip A feature of neurodegenerative disease is the accumulation of insoluble protein aggregates in the brain. In some conditions, including Amyotrophic Lateral Sclerosis and Frontotemporal lobar degeneration, the primary aggregating entities are RNA binding proteins. Through regulated prion-like assembly, RNA binding proteins serve many functions in RNA metabolism that are essential for the healthy maintenance of cells of the central nervous system. Those RNA binding proteins that are the core nucleating factors of stress granules (SGs), including TIA-1, TIAR, TTP and G3BP1, are also found in the pathological lesions of other neurological conditions, such as Alzheimer's disease, where the hallmark aggregating protein is not an RNA binding protein. This discovery suggests that the regulated cellular pathway, which utilizes assembly of RNA binding proteins to package and silence mRNAs during stress, may be integral in the aberrant pathological protein aggregation that occurs in numerous neurodegenerative conditions. Twit Text FOAVip Pathological stress granules in Alzheimer s disease ????Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=25108040 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25108040 #FOAvip English Wikipedia <ref>{{Cite pmid|25108040 }}</ref> Pathological stress granules in Alzheimer s disease #MMPMID25108040 Ash PE ; Vanderweyde TE ; Youmans KL ; Apicco DJ ; Wolozin B Brain Res 2014[Oct]; 1584 (ä): 52-8 PMID25108040 show ga A feature of neurodegenerative disease is the accumulation of insoluble protein aggregates in the brain. In some conditions, including Amyotrophic Lateral Sclerosis and Frontotemporal lobar degeneration, the primary aggregating entities are RNA binding proteins. Through regulated prion-like assembly, RNA binding proteins serve many functions in RNA metabolism that are essential for the healthy maintenance of cells of the central nervous system. Those RNA binding proteins that are the core nucleating factors of stress granules (SGs), including TIA-1, TIAR, TTP and G3BP1, are also found in the pathological lesions of other neurological conditions, such as Alzheimer's disease, where the hallmark aggregating protein is not an RNA binding protein. This discovery suggests that the regulated cellular pathway, which utilizes assembly of RNA binding proteins to package and silence mRNAs during stress, may be integral in the aberrant pathological protein aggregation that occurs in numerous neurodegenerative conditions. |*Stress, Physiological [MESH] |Alzheimer Disease/*metabolism/*pathology [MESH] |Animals [MESH] |Brain/metabolism/pathology [MESH] |Carrier Proteins/metabolism [MESH] |Cytoplasmic Granules/*metabolism/*pathology [MESH] |DNA Helicases [MESH] |DNA-Binding Proteins/metabolism [MESH] |Humans [MESH] |Mice [MESH] |Poly(A)-Binding Proteins/metabolism [MESH] |Poly-ADP-Ribose Binding Proteins [MESH] |Protein Aggregation, Pathological/*metabolism [MESH] |RNA Helicases [MESH] |RNA Recognition Motif Proteins [MESH] |RNA-Binding Proteins/metabolism [MESH] |Signal Transduction [MESH] |T-Cell Intracellular Antigen-1 [MESH]Pathological stress granules in Alzheimer s disease (epmc).pdf DeepDyve Pubget Overpricing