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2015 ; 7
(ä): 44
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Pathogenesis of Crohn s disease
#MMPMID26097717
Boyapati R
; Satsangi J
; Ho GT
F1000Prime Rep
2015[]; 7
(ä): 44
PMID26097717
show ga
Significant progress in our understanding of Crohn's disease (CD), an archetypal
common, complex disease, has now been achieved. Our ability to interrogate the
deep complexities of the biological processes involved in maintaining gut mucosal
homeostasis is a major over-riding factor underpinning this rapid progress. Key
studies now offer many novel and expansive insights into the interacting roles of
genetic susceptibility, immune function, and the gut microbiota in CD. Here, we
provide overviews of these recent advances and new mechanistic themes, and
address the challenges and prospects for translation from concept to clinic.