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10.3748/wjg.v23.i14.2459 http://scihub22266oqcxt.onion/10.3748/wjg.v23.i14.2459 C5394509!5394509 !28465630     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28465630 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       World+J+Gastroenterol 2017 ; 23 (14 ): 2459-2469 Nephropedia Template TP {{tp|p=28465630 |t=2017. Pathogenesis and clinical spectrum of primary sclerosing cholangitis |pdf=|usr=}}{{28465630 }} gab.com Text Pathogenesis and clinical spectrum of primary sclerosing cholangitis JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28465630 #FOAvip Primary sclerosing cholangitis (PSC) is a disease of the biliary tract, which has been documented in the literature since 1867. This disease has a strong predilection for affecting men and can be seen in individuals as young as 2 years of age. PSC has a strong associated with inflammatory bowel disease, more commonly with ulcerative colitis, and is also part of the clinical spectrum of IgG4-related diseases. Small-duct PSC, a variant of PSC, also has an association with inflammatory bowel disease. The exact pathogenesis of PSC is not well understood at present, however, is likely a combination of a genetic predisposition with alteration of the molecular structure of the gut. Abnormal serum liver chemistry and presence of certain autoimmune markers are usually the first indicators leading to a diagnosis of PCS, however, these may often be normal in early stages of this disease. The diagnosis is made by cholangiography, which is now considered the gold standard. PSC is a known pre-malignant condition. Such patients have an increased risk of developing cholangiocarcinoma, gallbladder neoplasia, and colon cancer. Many new treatment modalities have emerged in the recent past, including anti-tumor necrosis factor- ? and anti-integrins; however, liver transplantation is the only known cure for PSC. Despite past and present research, PSC remains an enigmatic biliary disease with few viable treatment options. Twit Text FOAVip Pathogenesis and clinical spectrum of primary sclerosing cholangitis ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28465630 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28465630 #FOAvip English Wikipedia <ref>{{Cite pmid|28465630 }}</ref> Pathogenesis and clinical spectrum of primary sclerosing cholangitis #MMPMID28465630 Gidwaney NG ; Pawa S ; Das KM World J Gastroenterol 2017[Apr]; 23 (14 ): 2459-2469 PMID28465630 show ga Primary sclerosing cholangitis (PSC) is a disease of the biliary tract, which has been documented in the literature since 1867. This disease has a strong predilection for affecting men and can be seen in individuals as young as 2 years of age. PSC has a strong associated with inflammatory bowel disease, more commonly with ulcerative colitis, and is also part of the clinical spectrum of IgG4-related diseases. Small-duct PSC, a variant of PSC, also has an association with inflammatory bowel disease. The exact pathogenesis of PSC is not well understood at present, however, is likely a combination of a genetic predisposition with alteration of the molecular structure of the gut. Abnormal serum liver chemistry and presence of certain autoimmune markers are usually the first indicators leading to a diagnosis of PCS, however, these may often be normal in early stages of this disease. The diagnosis is made by cholangiography, which is now considered the gold standard. PSC is a known pre-malignant condition. Such patients have an increased risk of developing cholangiocarcinoma, gallbladder neoplasia, and colon cancer. Many new treatment modalities have emerged in the recent past, including anti-tumor necrosis factor- ? and anti-integrins; however, liver transplantation is the only known cure for PSC. Despite past and present research, PSC remains an enigmatic biliary disease with few viable treatment options. |Animals [MESH] |Autoimmune Diseases/*complications/immunology [MESH] |Cholangitis, Sclerosing/*etiology/genetics/immunology/therapy [MESH] |Genetic Predisposition to Disease [MESH] |Humans [MESH] |Inflammation Mediators/immunology/metabolism [MESH] |Inflammatory Bowel Diseases/*complications/immunology [MESH] |Intestinal Mucosa/metabolism [MESH] |Intestines/immunology [MESH] |Phenotype [MESH] |Predictive Value of Tests [MESH] |Prognosis [MESH]Pathogenesis and clinical spectrum of primary sclerosing cholangitis (epmc).pdf DeepDyve Pubget Overpricing