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10.1111/jth.12939 http://scihub22266oqcxt.onion/10.1111/jth.12939 C4498406!4498406 !26149011     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26149011 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Thromb+Haemost 2015 ; 13 Suppl 1 (0 1 ): S106-14 Nephropedia Template TP {{tp|p=26149011 |t=2015. Pathogen activators of plasminogen |pdf=|usr=}}{{26149011 }} gab.com Text Pathogen activators of plasminogen JO: J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=26149011 #FOAvip Group A streptococci (GAS) express soluble and surface-bound virulence factors. Secreted streptokinase (SK) allelic variants exhibit varying abilities to activate host plasminogen (Pg), and GAS pathogenicity is associated with Pg activation and localization of the resulting plasmin (Pm) on the bacterial surface to promote dissemination. The various mechanisms by which GAS usurp the host proteolytic system are discussed, including the molecular sexuality mechanism of conformational activation of the Pg zymogen (Pg*) and subsequent proteolytic activation of substrate Pg by the S?KPg* and SK?Pm catalytic complexes. Substantial progress has been made to delineate both processes in a unified mechanism. Pm coats the bacteria by direct and indirect binding pathways involving plasminogen-binding group A streptococcal M-like (PAM) protein and host fibrin(ogen). Transgenic mouse models using human Pg are being optimized to mimic infections by SK variants in humans and to define in vivo combined mechanisms of these variants and PAM. Twit Text FOAVip Pathogen activators of plasminogen ????J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=26149011 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26149011 #FOAvip English Wikipedia <ref>{{Cite pmid|26149011 }}</ref> Pathogen activators of plasminogen #MMPMID26149011 Verhamme IM ; Panizzi PR ; Bock PE J Thromb Haemost 2015[Jun]; 13 Suppl 1 (0 1 ): S106-14 PMID26149011 show ga Group A streptococci (GAS) express soluble and surface-bound virulence factors. Secreted streptokinase (SK) allelic variants exhibit varying abilities to activate host plasminogen (Pg), and GAS pathogenicity is associated with Pg activation and localization of the resulting plasmin (Pm) on the bacterial surface to promote dissemination. The various mechanisms by which GAS usurp the host proteolytic system are discussed, including the molecular sexuality mechanism of conformational activation of the Pg zymogen (Pg*) and subsequent proteolytic activation of substrate Pg by the S?KPg* and SK?Pm catalytic complexes. Substantial progress has been made to delineate both processes in a unified mechanism. Pm coats the bacteria by direct and indirect binding pathways involving plasminogen-binding group A streptococcal M-like (PAM) protein and host fibrin(ogen). Transgenic mouse models using human Pg are being optimized to mimic infections by SK variants in humans and to define in vivo combined mechanisms of these variants and PAM. |*Fibrinolysis [MESH] |Animals [MESH] |Bacterial Proteins/metabolism [MESH] |Carrier Proteins/metabolism [MESH] |Fibrin/metabolism [MESH] |Fibrinolysin/*metabolism [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Models, Molecular [MESH] |Plasminogen/*metabolism [MESH] |Protein Binding [MESH] |Streptococcal Infections/*blood/microbiology [MESH] |Streptococcus pyogenes/*enzymology/pathogenicity [MESH] |Streptokinase/*metabolism [MESH] |Virulence [MESH]Pathogen activators of plasminogen (epmc).pdf DeepDyve Pubget Overpricing