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10.1111/imr.12446 http://scihub22266oqcxt.onion/10.1111/imr.12446 C5000857!5000857 !27558330     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27558330 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27558330 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunol+Rev 2016 ; 273 (1 ): 94-111 Nephropedia Template TP {{tp|p=27558330 |t=2016. Pathobiology of neutrophil-epithelial interactions |pdf=|usr=}}{{27558330 }} gab.com Text Pathobiology of neutrophil-epithelial interactions JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27558330 #FOAvip Polymorphonuclear neutrophils (PMNs) are innate immune system cells that play an essential role in eradicating invading pathogens. PMN migration to sites of infection/inflammation requires exiting the microcirculation and subsequent crossing of epithelial barriers in mucosa-lined organs such as the lungs and intestines. Although these processes usually occur without significant damage to surrounding host tissues, dysregulated/excessive PMN transmigration and resultant bystander-tissue damage are characteristic of numerous mucosal inflammatory disorders. Mechanisms controlling PMN extravasation have been well characterized, but the molecular details regarding regulation of PMN migration across mucosal epithelia are poorly understood. Given that PMN migration across mucosal epithelia is strongly correlated with disease symptoms in many inflammatory mucosal disorders, enhanced understanding of the mechanisms regulating PMN transepithelial migration should provide insights into clinically relevant tissue-targeted therapies aimed at ameliorating PMN-mediated bystander-tissue damage. This review will highlight current understanding of the molecular interactions between PMNs and mucosal epithelia and the associated functional consequences. Twit Text FOAVip Pathobiology of neutrophil-epithelial interactions ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27558330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27558330 #FOAvip English Wikipedia <ref>{{Cite pmid|27558330 }}</ref> Pathobiology of neutrophil-epithelial interactions #MMPMID27558330 Brazil JC ; Parkos CA Immunol Rev 2016[Sep]; 273 (1 ): 94-111 PMID27558330 show ga Polymorphonuclear neutrophils (PMNs) are innate immune system cells that play an essential role in eradicating invading pathogens. PMN migration to sites of infection/inflammation requires exiting the microcirculation and subsequent crossing of epithelial barriers in mucosa-lined organs such as the lungs and intestines. Although these processes usually occur without significant damage to surrounding host tissues, dysregulated/excessive PMN transmigration and resultant bystander-tissue damage are characteristic of numerous mucosal inflammatory disorders. Mechanisms controlling PMN extravasation have been well characterized, but the molecular details regarding regulation of PMN migration across mucosal epithelia are poorly understood. Given that PMN migration across mucosal epithelia is strongly correlated with disease symptoms in many inflammatory mucosal disorders, enhanced understanding of the mechanisms regulating PMN transepithelial migration should provide insights into clinically relevant tissue-targeted therapies aimed at ameliorating PMN-mediated bystander-tissue damage. This review will highlight current understanding of the molecular interactions between PMNs and mucosal epithelia and the associated functional consequences. |*Cell Movement [MESH] |*Immunity, Mucosal [MESH] |Animals [MESH] |Biological Therapy [MESH] |Cell Communication [MESH] |Epithelial Cells/*physiology [MESH] |Humans [MESH] |Inflammation/*immunology [MESH] |Neutrophil Infiltration [MESH]Pathobiology of neutrophil-epithelial interactions (epmc).pdf DeepDyve Pubget Overpricing