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2016 ; 2016
(ä): 1970843
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Parthenogenesis and Human Assisted Reproduction
#MMPMID26635881
Bos-Mikich A
; Bressan FF
; Ruggeri RR
; Watanabe Y
; Meirelles FV
Stem Cells Int
2016[]; 2016
(ä): 1970843
PMID26635881
show ga
Parthenogenetic activation of human oocytes obtained from infertility treatments
has gained new interest in recent years as an alternative approach to create
embryos with no reproductive purpose for research in areas such as assisted
reproduction technologies itself, somatic cell, and nuclear transfer experiments
and for derivation of clinical grade pluripotent embryonic stem cells for
regenerative medicine. Different activating methods have been tested on human and
nonhuman oocytes, with varying degrees of success in terms of parthenote
generation rates, embryo development stem cell derivation rates. Success in
achieving a standardized artificial activation methodology for human oocytes and
the subsequent potential therapeutic gain obtained from these embryos depends
mainly on the availability of gametes donated from infertility treatments. This
review will focus on the creation of parthenotes from clinically unusable oocytes
for derivation and establishment of human parthenogenetic stem cell lines and
their potential applications in regenerative medicine.
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