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10.2741/3297 http://scihub22266oqcxt.onion/10.2741/3297 C4450718!4450718 !19273119     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19273119 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Biosci+(Landmark+Ed) 2009 ; 14 (3 ): 1116-28 Nephropedia Template TP {{tp|p=19273119 |t=2009. Parthanatos, a messenger of death |pdf=|usr=}}{{19273119 }} gab.com Text Parthanatos, a messenger of death JO: Front Biosci (Landmark Ed) http://www.kidney.de/pget.php?&tw=1&pmid=19273119 #FOAvip Poly-ADP-ribose polymerase-1 (PARP-1)'s roles in the cell span from maintaining life to inducing death. The processes PARP-1 is involved in include DNA repair, DNA transcription, mitosis, and cell death. Of PARP-1's different cellular functions, its role in cell death is of particular interest to designing therapies for diseases. Genetic deletion of PARP-1 revealed that PARP-1 overactivation underlies cell death in models of stroke, diabetes, inflammation and neurodegeneration. Since interfering with PARP-1 mediated cell death will be clinically beneficial, great effort has been invested into understanding mechanisms downstream of PARP-1 overactivation. Recent evidence shows that poly-ADP ribose (PAR) polymer itself can act as a cell death effector downstream of PARP-1. We coined the term parthanatos after Thanatos, the personification of death in Greek mythology, to refer to PAR-mediated cell death. In this review, we will present evidence and questions raised by these recent findings, and summarize the proposed mechanisms by which PARP-1 overactivation kills. It is evident that further understanding of parthanatos opens up new avenues for therapy in ameliorating diseases related to PARP-1 overactivation. Twit Text FOAVip Parthanatos, a messenger of death ????Front Biosci (Landmark Ed) http://www.kidney.de/pget.php?&tw=1&pmid=19273119 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19273119 #FOAvip English Wikipedia <ref>{{Cite pmid|19273119 }}</ref> Parthanatos, a messenger of death #MMPMID19273119 David KK ; Andrabi SA ; Dawson TM ; Dawson VL Front Biosci (Landmark Ed) 2009[Jan]; 14 (3 ): 1116-28 PMID19273119 show ga Poly-ADP-ribose polymerase-1 (PARP-1)'s roles in the cell span from maintaining life to inducing death. The processes PARP-1 is involved in include DNA repair, DNA transcription, mitosis, and cell death. Of PARP-1's different cellular functions, its role in cell death is of particular interest to designing therapies for diseases. Genetic deletion of PARP-1 revealed that PARP-1 overactivation underlies cell death in models of stroke, diabetes, inflammation and neurodegeneration. Since interfering with PARP-1 mediated cell death will be clinically beneficial, great effort has been invested into understanding mechanisms downstream of PARP-1 overactivation. Recent evidence shows that poly-ADP ribose (PAR) polymer itself can act as a cell death effector downstream of PARP-1. We coined the term parthanatos after Thanatos, the personification of death in Greek mythology, to refer to PAR-mediated cell death. In this review, we will present evidence and questions raised by these recent findings, and summarize the proposed mechanisms by which PARP-1 overactivation kills. It is evident that further understanding of parthanatos opens up new avenues for therapy in ameliorating diseases related to PARP-1 overactivation. |Animals [MESH] |Cell Death/*physiology [MESH] |Humans [MESH] |Poly (ADP-Ribose) Polymerase-1 [MESH]Parthanatos, a messenger of death (epmc).pdf DeepDyve Pubget Overpricing