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2017 ; 5
(3
): 55-62
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Parsley! Mechanism as antiurolithiasis remedy
#MMPMID29181438
Al-Yousofy F
; Gumaih H
; Ibrahim H
; Alasbahy A
Am J Clin Exp Urol
2017[]; 5
(3
): 55-62
PMID29181438
show ga
Parsley is a medicinal plant used widely in urolithiasis. The present study aimed
to evaluate the antiurolithiatic effect of parsley and its mechanism. 24 rats
divided into four groups: group A (negative control), group B (positive control),
group C (cystone(®) group) and group D (parsley group). Group B were treated with
EG and Ammonium chloride (AC). Group C were treated as B plus cystone(®) and
group D was treated as B plus parsley. The period of experiment was 15 days.
Urine samples were analysis on days 0 and 15 days. Kidneys of rats from all
groups were removed, and histopathologically examined. The kidnies of parsley
treated group appeared mostly to be calculi-free (less CaOx) even better than the
cystone treated group. CaOx crystals was significantly lower both in histological
sections and in urine samples in parsley treated group. We further investigated
the mechanism of parsley by adding another 6 rats. The latter treated by parsley
only after adaptation period. We found significant increase in urine volume and
pH in parsley treated rats compared to negative control. We concluded that
parsley acts as antiurolithiatic drug through decreasing urinary calcium
excretion, increasing urinary pH, dieresis, decreasing urinary protein excretion
and its nephroprtective activity. We recommended to use it in pharmaceutical
forms as it is safe and effective as antiurolithiasis remedy.
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