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10.1016/j.hoc.2015.01.005 http://scihub22266oqcxt.onion/10.1016/j.hoc.2015.01.005 C4695989!4695989 !26043387     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26043387 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hematol+Oncol+Clin+North+Am 2015 ; 29 (3 ): 479-94 Nephropedia Template TP {{tp|p=26043387 |t=2015. Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic anemia |pdf=|usr=}}{{26043387 }} gab.com Text Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic anemia JO: Hematol Oncol Clin North Am http://www.kidney.de/pget.php?&tw=1&pmid=26043387 #FOAvip Paroxysmal nocturnal hemoglobinuria is manifests with a chronic hemolytic anemia from uncontrolled complement activation, a propensity for thrombosis and marrow failure. The hemolysis is largely mediated by the alternative pathway of complement. Clinical manifestations result from the lack of specific cell surface proteins, CD55 and CD59, on PNH cells. Complement inhibition by eculizumab leads to dramatic clinical improvement. While this therapeutic approach is effective, there is residual complement activity resulting from specific clinical scenarios as well as from upstream complement components that can account for suboptimal responses in some patients. Complement inhibition strategies are an area of active research. Twit Text FOAVip Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic anemia ????Hematol Oncol Clin North Am http://www.kidney.de/pget.php?&tw=1&pmid=26043387 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26043387 #FOAvip English Wikipedia <ref>{{Cite pmid|26043387 }}</ref> Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic anemia #MMPMID26043387 DeZern AE ; Brodsky RA Hematol Oncol Clin North Am 2015[Jun]; 29 (3 ): 479-94 PMID26043387 show ga Paroxysmal nocturnal hemoglobinuria is manifests with a chronic hemolytic anemia from uncontrolled complement activation, a propensity for thrombosis and marrow failure. The hemolysis is largely mediated by the alternative pathway of complement. Clinical manifestations result from the lack of specific cell surface proteins, CD55 and CD59, on PNH cells. Complement inhibition by eculizumab leads to dramatic clinical improvement. While this therapeutic approach is effective, there is residual complement activity resulting from specific clinical scenarios as well as from upstream complement components that can account for suboptimal responses in some patients. Complement inhibition strategies are an area of active research. |Anemia, Hemolytic/*immunology [MESH] |Antibodies, Monoclonal, Humanized/immunology/therapeutic use [MESH] |CD55 Antigens/immunology/metabolism [MESH] |CD59 Antigens/immunology/metabolism [MESH] |Complement Activation/drug effects/*immunology [MESH] |Complement System Proteins/*immunology [MESH] |Hemoglobinuria, Paroxysmal/*immunology/metabolism/prevention & control [MESH] |Humans [MESH]Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic a(epmc).pdf DeepDyve Pubget Overpricing