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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neurosci
2017 ; 37
(41
): 9799-9807
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Parkinson s Disease Is Not Simply a Prion Disorder
#MMPMID29021297
Surmeier DJ
; Obeso JA
; Halliday GM
J Neurosci
2017[Oct]; 37
(41
): 9799-9807
PMID29021297
show ga
The notion that prion-like spreading of misfolded ?-synuclein (?-SYN) causes
Parkinson's disease (PD) has received a great deal of attention. Although
attractive in its simplicity, the hypothesis is difficult to reconcile with
postmortem analysis of human brains and connectome-mapping studies. An
alternative hypothesis is that PD pathology is governed by regional or
cell-autonomous factors. Although these factors provide an explanation for the
pattern of neuronal loss in PD, they do not readily explain the apparently staged
distribution of Lewy pathology in many PD brains, the feature of the disease that
initially motivated the spreading hypothesis by Braak and colleagues. While each
hypothesis alone has its shortcomings, a synthesis of the two can explain much of
what we know about the etiopathology of PD.Dual Perspectives Companion Paper:
Prying into the Prion Hypothesis for Parkinson's Disease, by Patrik Brundin and
Ronald Melki.
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