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2015 ; 4
(4
): 329-38
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Parathyroid cancer
#MMPMID26312219
McClenaghan F
; Qureshi YA
Gland Surg
2015[Aug]; 4
(4
): 329-38
PMID26312219
show ga
Parathyroid carcinoma is an exceedingly rare endocrine malignancy first described
in 1933. It accounts for between 0.5% and 5% of all cases of primary
hyperparathyroidism. Parathyroid carcinoma is unusual among endocrine
malignancies, being more hormonally active than its benign counterpart.
Parathyroid carcinoma poses a diagnostic challenge both clinically and
histologically due to the lack of features which can definitively distinguish
malignant from benign disease early in its clinical course. Here, we describe the
clinical features of the disease, and present the current opinion on optimal
management. Further, we analyse the most recent histological advances made to aid
in the diagnosis and management of this rare, but potentially devastating,
disease.