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10.1182/blood-2014-03-562538

http://scihub22266oqcxt.onion/10.1182/blood-2014-03-562538
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suck abstract from ncbi


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pmid24868077
      Blood 2014 ; 124 (2 ): 184-7
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  • Paraneoplastic thrombocytosis: the secrets of tumor self-promotion #MMPMID24868077
  • Lin RJ ; Afshar-Kharghan V ; Schafer AI
  • Blood 2014[Jul]; 124 (2 ): 184-7 PMID24868077 show ga
  • Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet activation. Specific molecular pathways have been identified in which tumors can stimulate platelet production and activation; activated platelets can, in turn, promote tumor growth and metastasis. Taken together, these findings provide exciting new potential targets for therapeutic intervention.
  • |Animals [MESH]
  • |Antineoplastic Agents/therapeutic use [MESH]
  • |Blood Platelets/pathology/physiology [MESH]
  • |Cell Proliferation [MESH]
  • |Humans [MESH]
  • |Molecular Targeted Therapy [MESH]
  • |Paraneoplastic Syndromes/drug therapy/etiology/*pathology [MESH]
  • |Thrombocytosis/drug therapy/etiology/pathology [MESH]


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