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2014 ; 124
(2
): 184-7
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Paraneoplastic thrombocytosis: the secrets of tumor self-promotion
#MMPMID24868077
Lin RJ
; Afshar-Kharghan V
; Schafer AI
Blood
2014[Jul]; 124
(2
): 184-7
PMID24868077
show ga
Paraneoplastic thrombocytosis is associated with many solid tumors and often
correlates with reduced survival. Recent studies suggest that a pathogenic feed
back loop may be operative between platelets and tumor cells, with reciprocal
interactions between tumor growth/metastasis and thrombocytosis/platelet
activation. Specific molecular pathways have been identified in which tumors can
stimulate platelet production and activation; activated platelets can, in turn,
promote tumor growth and metastasis. Taken together, these findings provide
exciting new potential targets for therapeutic intervention.