Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25396312
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25396312
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Thorac+Oncol
2014 ; 9
(9 Suppl 2
): S143-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Paraneoplastic disorders in thymoma patients
#MMPMID25396312
Evoli A
; Lancaster E
J Thorac Oncol
2014[Sep]; 9
(9 Suppl 2
): S143-7
PMID25396312
show ga
Thymic malignancy is often associated with paraneoplastic neurological diseases
(PNDs) and recognition of these disorders is important for physicians who treat
these patients. The most common thymoma-associated PNDs are myasthenia gravis
(MG), acquired neuromyotonia (Isaacs' syndrome), encephalitis, Morvan's syndrome,
and myositis. Diagnosis of these disorders is complex but often aided by testing
for specific autoantibodies, including those to the acetylcholine receptor for MG
and to contactin-associated protein-like 2, protein of the voltage-gated
potassium channel complex, in patients with acquired neuromyotonia, Morvan's
syndrome, or encephalitis. Patients who manifest these disorders should be
screened for thymoma at diagnosis, and worsening of these PNDs may be associated
with recurrent thymoma. These disorders can cause profound disability but usually
respond to immunotherapy, and often improve with thymoma treatment. Close
cooperation among a team of specialists is required to take proper care of these
patients.