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10.1097/JTO.0000000000000300

http://scihub22266oqcxt.onion/10.1097/JTO.0000000000000300
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C4234178!4234178!25396312
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suck abstract from ncbi


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pmid25396312      J+Thorac+Oncol 2014 ; 9 (9 0 2): S143-7
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  • Paraneoplastic disorders in thymoma patients #MMPMID25396312
  • Lancaster E; Evoli A
  • J Thorac Oncol 2014[Sep]; 9 (9 0 2): S143-7 PMID25396312show ga
  • Thymic malignancy is often associated with paraneoplastic neurological diseases (PNDs) and recognition of these disorders is important for physicians who treat these patients. The most common thymoma-associated PNDs are myasthenia gravis, acquired neuromyotonia (Isaacs' syndrome), encephalitis, Morvan's syndrome, and myositis. Diagnosis of these disorders is complex but often aided by testing for specific autoantibodies, including those to the acetylcholine receptor (AChR) for myasthenia gravis and to Caspr2, protein of the voltage-gated potassium channel (VGKC) complex, in patients with acquired neuromyotonia, Morvan's syndrome, or encephalitis. Patients who manifest these disorders should be screened for thymoma at diagnosis, and worsening of these PNDs may be associated with recurrent thymoma. These disorders can cause profound disability but usually respond to immunotherapy, and often improve with thymoma treatment. Close cooperation among a team of specialists is required to properly care for these patients.
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