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2017 ; 40
(1
): 1-21
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Papillomaviruses: a systematic review
#MMPMID28212457
Araldi RP
; Assaf SMR
; Carvalho RF
; Carvalho MACR
; Souza JM
; Magnelli RF
; Módolo DG
; Roperto FP
; Stocco RC
; Beçak W
Genet Mol Biol
2017[Jan]; 40
(1
): 1-21
PMID28212457
show ga
In the last decades, a group of viruses has received great attention due to its
relationship with cancer development and its wide distribution throughout the
vertebrates: the papillomaviruses. In this article, we aim to review some of the
most relevant reports concerning the use of bovines as an experimental model for
studies related to papillomaviruses. Moreover, the obtained data contributes to
the development of strategies against the clinical consequences of bovine
papillomaviruses (BPV) that have led to drastic hazards to the herds. To overcome
the problem, the vaccines that we have been developing involve recombinant DNA
technology, aiming at prophylactic and therapeutic procedures. It is important to
point out that these strategies can be used as models for innovative procedures
against HPV, as this virus is the main causal agent of cervical cancer, the
second most fatal cancer in women.