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2015 ; 7
(8
): 4303-25
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English Wikipedia
Papillomavirus Infectious Pathways: A Comparison of Systems
#MMPMID26247955
Biryukov J
; Meyers C
Viruses
2015[Aug]; 7
(8
): 4303-25
PMID26247955
show ga
The HPV viral lifecycle is tightly linked to the host cell differentiation,
causing difficulty in growing virions in culture. A system that bypasses the need
for differentiating epithelium has allowed for generation of recombinant
particles, such as virus-like particles (VLPs), pseudovirions (PsV), and
quasivirions (QV). Much of the research looking at the HPV life cycle,
infectivity, and structure has been generated utilizing recombinant particles.
While recombinant particles have proven to be invaluable, allowing for a rapid
progression of the HPV field, there are some significant differences between
recombinant particles and native virions and very few comparative studies using
native virions to confirm results are done. This review serves to address the
conflicting data in the HPV field regarding native virions and recombinant
particles.
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