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2017 ; 1864
(1
): 51-61
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Pannexin1 as mediator of inflammation and cell death
#MMPMID27741412
Crespo Yanguas S
; Willebrords J
; Johnstone SR
; Maes M
; Decrock E
; De Bock M
; Leybaert L
; Cogliati B
; Vinken M
Biochim Biophys Acta Mol Cell Res
2017[Jan]; 1864
(1
): 51-61
PMID27741412
show ga
Pannexins form channels at the plasma membrane surface that establish a pathway
for communication between the cytosol of individual cells and their extracellular
environment. By doing so, pannexin signaling dictates several physiological
functions, but equally underlies a number of pathological processes. Indeed,
pannexin channels drive inflammation by assisting in the activation of
inflammasomes, the release of pro-inflammatory cytokines, and the activation and
migration of leukocytes. Furthermore, these cellular pores facilitate cell death,
including apoptosis, pyroptosis and autophagy. The present paper reviews the
roles of pannexin channels in inflammation and cell death. In a first part, a
state-of-the-art overview of pannexin channel structure, regulation and function
is provided. In a second part, the mechanisms behind their involvement in
inflammation and cell death are discussed.
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