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10.1016/j.gendis.2015.01.002 http://scihub22266oqcxt.onion/10.1016/j.gendis.2015.01.002 C4476547!4476547 !26114155     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26114155 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dis 2015 ; 2 (2 ): 133-143 Nephropedia Template TP {{tp|p=26114155 |t=2015. Pancreatic cancer stromal biology and therapy |pdf=|usr=}}{{26114155 }} gab.com Text Pancreatic cancer stromal biology and therapy JO: Genes Dis http://www.kidney.de/pget.php?&tw=1&pmid=26114155 #FOAvip Pancreatic cancer is one of the most lethal malignancies. Significant progresses have been made in understanding of pancreatic cancer pathogenesis, including appreciation of precursor lesions or premalignant pancreatic intraepithelial neoplasia (PanINs), description of sequential transformation from normal pancreatic tissue to invasive pancreatic cancer and identification of major genetic and epigenetic events and the biological impact of those events on malignant behavior. However, the currently used therapeutic strategies targeting tumor epithelial cells, which are potent in cell culture and animal models, have not been successful in the clinic. Presumably, therapeutic resistance of pancreatic cancer is at least in part due to its drastic desmoplasis, which is a defining hallmark for and circumstantially contributes to pancreatic cancer development and progression. Improved understanding of the dynamic interaction between cancer cells and the stroma is important to better understanding pancreatic cancer biology and to designing effective intervention strategies. This review focuses on the origination, evolution and disruption of stromal molecular and cellular components in pancreatic cancer, and their biological effects on pancreatic cancer pathogenesis. Twit Text FOAVip Pancreatic cancer stromal biology and therapy ????Genes Dis http://www.kidney.de/pget.php?&tw=1&pmid=26114155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26114155 #FOAvip English Wikipedia <ref>{{Cite pmid|26114155 }}</ref> Pancreatic cancer stromal biology and therapy #MMPMID26114155 Xie D ; Xie K Genes Dis 2015[Jun]; 2 (2 ): 133-143 PMID26114155 show ga Pancreatic cancer is one of the most lethal malignancies. Significant progresses have been made in understanding of pancreatic cancer pathogenesis, including appreciation of precursor lesions or premalignant pancreatic intraepithelial neoplasia (PanINs), description of sequential transformation from normal pancreatic tissue to invasive pancreatic cancer and identification of major genetic and epigenetic events and the biological impact of those events on malignant behavior. However, the currently used therapeutic strategies targeting tumor epithelial cells, which are potent in cell culture and animal models, have not been successful in the clinic. Presumably, therapeutic resistance of pancreatic cancer is at least in part due to its drastic desmoplasis, which is a defining hallmark for and circumstantially contributes to pancreatic cancer development and progression. Improved understanding of the dynamic interaction between cancer cells and the stroma is important to better understanding pancreatic cancer biology and to designing effective intervention strategies. This review focuses on the origination, evolution and disruption of stromal molecular and cellular components in pancreatic cancer, and their biological effects on pancreatic cancer pathogenesis. äPancreatic cancer stromal biology and therapy (epmc).pdf DeepDyve Pubget Overpricing