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Am J Cancer Res
2015[]; 5
(3
): 894-906
PMID26045976
show ga
Studies are emerging in support of the cancer stem cells (CSCs) theory which
considers that a tiny subset of cancer cells is exclusively responsible for the
initiation and malignant behavior of a cancer. This cell population, also termed
CSCs, possesses the capacity both to self-renew, producing progeny that have the
identical tumorigenic potential, and to differentiate into the bulk of cancer
cells, helping serve the formation of the tumor entities, which, altogether,
build the hierarchically organized structure of a cancer. In this review, we try
to articulate the complicated signaling pathways regulating the retention of the
characteristics of pancreatic CSCs, and in the wake of which, we seek to offer
insights into the CSCs-relevant targeted therapeutics which are, in the meantime,
confronted with bigger challenges than ever.
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