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2016 ; 354
(6312
): 572-577
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Pain regulation by non-neuronal cells and inflammation
#MMPMID27811267
Ji RR
; Chamessian A
; Zhang YQ
Science
2016[Nov]; 354
(6312
): 572-577
PMID27811267
show ga
Acute pain is protective and a cardinal feature of inflammation. Chronic pain
after arthritis, nerve injury, cancer, and chemotherapy is associated with
chronic neuroinflammation, a local inflammation in the peripheral or central
nervous system. Accumulating evidence suggests that non-neuronal cells such as
immune cells, glial cells, keratinocytes, cancer cells, and stem cells play
active roles in the pathogenesis and resolution of pain. We review how
non-neuronal cells interact with nociceptive neurons by secreting neuroactive
signaling molecules that modulate pain. Recent studies also suggest that
bacterial infections regulate pain through direct actions on sensory neurons, and
specific receptors are present in nociceptors to detect danger signals from
infections. We also discuss new therapeutic strategies to control
neuroinflammation for the prevention and treatment of chronic pain.
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