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2017 ; 5
(ä): 31
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PTK7 Faces the Wnt in Development and Disease
#MMPMID28424771
Berger H
; Wodarz A
; Borchers A
Front Cell Dev Biol
2017[]; 5
(ä): 31
PMID28424771
show ga
PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane
receptor regulating various processes in embryonic development and tissue
homeostasis. On a cellular level PTK7 affects the establishment of cell polarity,
the regulation of cell movement and migration as well as cell invasion. The PTK7
receptor has been shown to interact with ligands, co-receptors, and intracellular
transducers of Wnt signaling pathways, pointing to a function in the fine-tuning
of the Wnt signaling network. Here we will review recent findings implicating
PTK7 at the crossroads of Wnt signaling pathways in development and disease.