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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nat+Commun
2015 ; 6
(ä): 8388
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PTEN regulates cilia through Dishevelled
#MMPMID26399523
Shnitsar I
; Bashkurov M
; Masson GR
; Ogunjimi AA
; Mosessian S
; Cabeza EA
; Hirsch CL
; Trcka D
; Gish G
; Jiao J
; Wu H
; Winklbauer R
; Williams RL
; Pelletier L
; Wrana JL
; Barrios-Rodiles M
Nat Commun
2015[Sep]; 6
(ä): 8388
PMID26399523
show ga
Cilia are hair-like cellular protrusions important in many aspects of eukaryotic
biology. For instance, motile cilia enable fluid movement over epithelial
surfaces, while primary (sensory) cilia play roles in cellular signalling. The
molecular events underlying cilia dynamics, and particularly their disassembly,
are not well understood. Phosphatase and tensin homologue (PTEN) is an
extensively studied tumour suppressor, thought to primarily act by antagonizing
PI3-kinase signalling. Here we demonstrate that PTEN plays an important role in
multicilia formation and cilia disassembly by controlling the phosphorylation of
Dishevelled (DVL), another ciliogenesis regulator. DVL is a central component of
WNT signalling that plays a role during convergent extension movements, which we
show here are also regulated by PTEN. Our studies identify a novel protein
substrate for PTEN that couples PTEN to regulation of cilia dynamics and WNT
signalling, thus advancing our understanding of potential underlying molecular
etiologies of PTEN-related pathologies.
|Adaptor Proteins, Signal Transducing/*metabolism
[MESH]
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