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2018 ; 15
(4
): 4669-4675
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PRR4: A novel downregulated gene in laryngeal cancer
#MMPMID29541239
Ekizoglu S
; Ulutin T
; Guliyev J
; Buyru N
Oncol Lett
2018[Apr]; 15
(4
): 4669-4675
PMID29541239
show ga
Head and neck squamous cell carcinomas (HNSCC) are a diverse group of tumor
types, including neoplasia of the paranasal sinuses, oral cavity, trachea,
pharynx and larynx. Laryngeal cancer is the most common type of HNSCC. The
proline-rich 4 (PRR4) protein is synthesized in the acinar cells of human
lacrimal glands. Previous studies have demonstrated that PRR4 may function as an
antimicrobial protein protecting the ocular surface and the oral cavity. In order
to determine differentially expressed genes (DEGs) in laryngeal tumors, a
GeneFishing Assay was performed; 27 DEGs were identified. The PRR4 gene
expression level in laryngeal tissue samples obtained from 90 patients, and the
saliva of 25 healthy smokers and 25 non-smokers, was investigated using reverse
transcription-quantitative polymerase chain reaction. It was revealed that PRR4
gene expression was decreased in 65/90 tumor tissues (72.2%) compared with normal
tissues. No significant difference was identified between the healthy smoker and
the non-smoker groups in terms of PRR4 gene expression. The results of the
present study indicated that the PRR4 gene may serve an important role in
laryngeal carcinogenesis.
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