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2018 ; 4
(2
): dvy007
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POHaD: why we should study future fathers
#MMPMID29732171
Soubry A
Environ Epigenet
2018[Apr]; 4
(2
): dvy007
PMID29732171
show ga
The growing field of 'Developmental Origin of Health and Disease' (DOHaD)
generally reflects environmental influences from mother to child. The importance
of maternal lifestyle, diet and other environmental exposures before and during
gestation period is well recognized. However, few epidemiological designs explore
potential influences from the paternal environment on offspring health. This is
surprising given that numerous animal models have provided evidence that the
paternal environment plays a role in a non-genetic inheritance of
pre-conceptional exposures through the male germ line. Recent findings in humans
suggest that the epigenome of sperm cells can indeed be affected by paternal
exposures. Defects in epigenetic sperm mechanisms may result in persistent
modifications, affecting male fertility or offspring health status. We addressed
this issue at the LATSIS Symposium 'Transgenerational Epigenetic Inheritance:
Impact for Biology and Society', in Zürich, 28-30 August 2017, and here provide
important arguments why environmental and lifestyle-related exposures in young
men should be studied. The Paternal Origins of Health and Disease (POHaD)
paradigm was introduced to stress the need for more research on the role of the
father in the transmission of acquired environmental messages from his
environment to his offspring. A better understanding of pre-conceptional origins
of disease through the paternal exposome will be informative to the field of
transgenerational epigenetics and will ultimately help instruct and guide public
health policies in the future.
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