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10.1016/j.celrep.2016.05.015 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.05.015 C4899214!4899214 !27239040     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27239040 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2016 ; 15 (10 ): 2266-2278 Nephropedia Template TP {{tp|p=27239040 |t=2016. PIAS1 Promotes Lymphomagenesis through MYC Upregulation |pdf=|usr=}}{{27239040 }} gab.com Text PIAS1 Promotes Lymphomagenesis through MYC Upregulation JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27239040 #FOAvip The MYC proto-oncogene is a transcription factor implicated in a broad range of cancers. MYC is regulated by several post-translational modifications including SUMOylation, but the functional impact of this post-translational modification is still unclear. Here, we report that the SUMO E3 ligase PIAS1 SUMOylates MYC. We demonstrate that PIAS1 promotes, in a SUMOylation-dependent manner, MYC phosphorylation at serine 62 and dephosphorylation at threonine 58. These events reduce the MYC turnover, leading to increased transcriptional activity. Furthermore, we find that MYC is SUMOylated in primary B cell lymphomas and that PIAS1 is required for the viability of MYC-dependent B cell lymphoma cells as well as several cancer cell lines of epithelial origin. Finally, Pias1-null mice display endothelial defects reminiscent of Myc-null mice. Taken together, these results indicate that PIAS1 is a positive regulator of MYC. Twit Text FOAVip PIAS1 Promotes Lymphomagenesis through MYC Upregulation ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27239040 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27239040 #FOAvip English Wikipedia <ref>{{Cite pmid|27239040 }}</ref> PIAS1 Promotes Lymphomagenesis through MYC Upregulation #MMPMID27239040 Rabellino A ; Melegari M ; Tompkins VS ; Chen W ; Van Ness BG ; Teruya-Feldstein J ; Conacci-Sorrell M ; Janz S ; Scaglioni PP Cell Rep 2016[Jun]; 15 (10 ): 2266-2278 PMID27239040 show ga The MYC proto-oncogene is a transcription factor implicated in a broad range of cancers. MYC is regulated by several post-translational modifications including SUMOylation, but the functional impact of this post-translational modification is still unclear. Here, we report that the SUMO E3 ligase PIAS1 SUMOylates MYC. We demonstrate that PIAS1 promotes, in a SUMOylation-dependent manner, MYC phosphorylation at serine 62 and dephosphorylation at threonine 58. These events reduce the MYC turnover, leading to increased transcriptional activity. Furthermore, we find that MYC is SUMOylated in primary B cell lymphomas and that PIAS1 is required for the viability of MYC-dependent B cell lymphoma cells as well as several cancer cell lines of epithelial origin. Finally, Pias1-null mice display endothelial defects reminiscent of Myc-null mice. Taken together, these results indicate that PIAS1 is a positive regulator of MYC. |*Gene Expression Regulation, Neoplastic [MESH] |Animals [MESH] |Carcinogenesis/genetics/*pathology [MESH] |Cell Line [MESH] |Cell Proliferation [MESH] |Cell Survival [MESH] |Half-Life [MESH] |Humans [MESH] |Lymphoma, B-Cell/*genetics/*pathology [MESH] |Mice [MESH] |Phosphorylation [MESH] |Phosphothreonine/metabolism [MESH] |Protein Binding/genetics [MESH] |Protein Inhibitors of Activated STAT/*metabolism [MESH] |Proteolysis [MESH] |Proto-Oncogene Mas [MESH] |Proto-Oncogene Proteins c-myc/*genetics/metabolism [MESH] |Sumoylation [MESH] |Transcription, Genetic [MESH]PIAS1 Promotes Lymphomagenesis through MYC Upregulation (epmc).pdf DeepDyve Pubget Overpricing