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2014 ; 43
(19
): 6683-91
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PET/SPECT imaging agents for neurodegenerative diseases
#MMPMID24676152
Zhu L
; Ploessl K
; Kung HF
Chem Soc Rev
2014[Oct]; 43
(19
): 6683-91
PMID24676152
show ga
Single photon emission computed tomography (SPECT) or positron emission computed
tomography (PET) imaging agents for neurodegenerative diseases have a significant
impact on clinical diagnosis and patient care. The examples of Parkinson's
Disease (PD) and Alzheimer's Disease (AD) imaging agents described in this paper
provide a general view on how imaging agents, i.e. radioactive drugs, are
selected, chemically prepared and applied in humans. Imaging the living human
brain can provide unique information on the pathology and progression of
neurodegenerative diseases, such as AD and PD. The imaging method will also
facilitate preclinical and clinical trials of new drugs offering specific
information related to drug binding sites in the brain. In the future, chemists
will continue to play important roles in identifying specific targets,
synthesizing target-specific probes for screening and ultimately testing them by
in vitro and in vivo assays.
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