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2018 ; 19
(1
): 160
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PDZscape: a comprehensive PDZ-protein database
#MMPMID29699484
Doshi J
; Kuppili RR
; Gurdasani S
; Venkatakrishnan N
; Saxena A
; Bose K
BMC Bioinformatics
2018[Apr]; 19
(1
): 160
PMID29699484
show ga
PDZ-containing proteins comprise one of the most widely distributed protein
families playing major role in localization and membrane receptor clustering.
They are hence important regulators of signal transduction in cellular pathways.
Although knowledge on these proteins has increased exponentially, the existing
database 'PDZBase' is limited by presence of only 339 proteins as it dates back
to 2004 when very little data was available. Thus, lack of exclusive information
on this protein family led us to develop PDZscape. 'PDZscape' encompasses the
complete available information on 58,648 PDZ-containing proteins with their known
and putative binding partners on one platform. It has a user-friendly web
interface that can be easily queried with external protein identifiers. With
unique integration of prominent databases including NCBI, UniProtKB, Swiss-Prot,
Pubmed, PDB, STRING, IntAct, KEGG, Pfam and Protein Mutant Database, it provides
detailed information on PDZ interactome apart from the customized BLAST option.
Most importantly, this database encompasses the mutations and diseases associated
with PDZ containing proteins manually curated by our group, thus making it a
comprehensive compilation. It also features tools to query the database using
sequence (PDZ-Blast) and to find if protein of interest is a PDZ-binding protein.
PDZscape is freely available at http://www.actrec.gov.in:8080/pdzscape .
free
free
free
