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10.1158/0008-5472.CAN-17-2175 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-17-2175 C5771812!5771812 !29311159     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29311159 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Res 2018 ; 78 (2 ): 313-319 Nephropedia Template TP {{tp|p=29311159 |t=2018. PD2/PAF1 at the Crossroads of the Cancer Network |pdf=|usr=}}{{29311159 }} gab.com Text PD2/PAF1 at the Crossroads of the Cancer Network JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=29311159 #FOAvip Pancreatic differentiation 2 (PD2)/RNA polymerase II-associated factor 1 (PAF1) is the core subunit of the human PAF1 complex (PAF1C) that regulates the promoter-proximal pausing of RNA polymerase II as well as transcription elongation and mRNA processing and coordinates events in mRNA stability and quality control. As an integral part of its transcription-regulatory function, PD2/PAF1 plays a role in posttranslational histone covalent modifications as well as regulates expression of critical genes of the cell-cycle machinery. PD2/PAF1 alone, and as a part of PAF1C, provides distinct roles in the maintenance of self-renewal of embryonic stem cells and cancer stem cells, and in lineage differentiation. Thus, PD2/PAF1 malfunction or its altered abundance is likely to affect normal cellular functions, leading to disease states. Indeed, PD2/PAF1 is found to be upregulated in poorly differentiated pancreatic cancer cells and has the capacity for neoplastic transformation when ectopically expressed in mouse fibroblast cells. Likewise, PD2/PAF1 is upregulated in pancreatic and ovarian cancer stem cells. Here, we concisely describe multifaceted roles of PD2/PAF1 associated with oncogenic transformation and implicate PD2/PAF1 as an attractive target for therapeutic development to combat malignancy. Cancer Res; 78(2); 313-9. ©2018 AACR. Twit Text FOAVip PD2/PAF1 at the Crossroads of the Cancer Network ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=29311159 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29311159 #FOAvip English Wikipedia <ref>{{Cite pmid|29311159 }}</ref> PD2/PAF1 at the Crossroads of the Cancer Network #MMPMID29311159 Karmakar S ; Dey P ; Vaz AP ; Bhaumik SR ; Ponnusamy MP ; Batra SK Cancer Res 2018[Jan]; 78 (2 ): 313-319 PMID29311159 show ga Pancreatic differentiation 2 (PD2)/RNA polymerase II-associated factor 1 (PAF1) is the core subunit of the human PAF1 complex (PAF1C) that regulates the promoter-proximal pausing of RNA polymerase II as well as transcription elongation and mRNA processing and coordinates events in mRNA stability and quality control. As an integral part of its transcription-regulatory function, PD2/PAF1 plays a role in posttranslational histone covalent modifications as well as regulates expression of critical genes of the cell-cycle machinery. PD2/PAF1 alone, and as a part of PAF1C, provides distinct roles in the maintenance of self-renewal of embryonic stem cells and cancer stem cells, and in lineage differentiation. Thus, PD2/PAF1 malfunction or its altered abundance is likely to affect normal cellular functions, leading to disease states. Indeed, PD2/PAF1 is found to be upregulated in poorly differentiated pancreatic cancer cells and has the capacity for neoplastic transformation when ectopically expressed in mouse fibroblast cells. Likewise, PD2/PAF1 is upregulated in pancreatic and ovarian cancer stem cells. Here, we concisely describe multifaceted roles of PD2/PAF1 associated with oncogenic transformation and implicate PD2/PAF1 as an attractive target for therapeutic development to combat malignancy. Cancer Res; 78(2); 313-9. ©2018 AACR. |*Gene Expression Regulation, Neoplastic [MESH] |Carcinogenesis/genetics/metabolism/*pathology [MESH] |Humans [MESH] |Neoplasms/genetics/metabolism/*pathology [MESH] |Nuclear Proteins/genetics/*metabolism [MESH]PD2/PAF1 at the Crossroads of the Cancer Network (epmc).pdf DeepDyve Pubget Overpricing