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10.18632/oncotarget.17232

http://scihub22266oqcxt.onion/10.18632/oncotarget.17232
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C5584302!5584302 !28881701
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suck abstract from ncbi


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pmid28881701
      Oncotarget 2017 ; 8 (31 ): 51936-51945
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  • PD1 signal transduction pathways in T cells #MMPMID28881701
  • Arasanz H ; Gato-Caņas M ; Zuazo M ; Ibaņez-Vea M ; Breckpot K ; Kochan G ; Escors D
  • Oncotarget 2017[Aug]; 8 (31 ): 51936-51945 PMID28881701 show ga
  • The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low toxicities. Despite all the recent advances, very little is yet known on the molecular intracellular signaling pathways regulated by either PD-L1 or PD1. Here we review the current knowledge on PD1-dependent intracellular signaling pathways, and the consequences of disrupting PD1 signal transduction.
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