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2015 ; 29
(6
): 429-436
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PCSK9 and triglyceride-rich lipoprotein metabolism
#MMPMID26320603
Druce I
; Abujrad H
; Ooi TC
J Biomed Res
2015[Nov]; 29
(6
): 429-436
PMID26320603
show ga
Pro-protein convertase subtilisin-kexin 9 (PCSK9) is known to affect low-density
lipoprotein (LDL) metabolism, but there are indications from several lines of
research that it may also influence the metabolism of other lipoproteins,
especially triglyceride-rich lipoproteins (TRL). This review summarizes the
current data on this possible role of PCSK9. A link between PCSK9 and TRL has
been suggested through the demonstration of (1) a correlation between plasma
PCSK9 and triglyceride (TG) levels in health and disease, (2) a correlation
between plasma PCSK9 and markers of carbohydrate metabolism, which is closely
related to TG metabolism, (3) an effect of TG-lowering fibrate therapy on plasma
PCSK9 levels, (4) an effect of PCSK9 on postprandial lipemia, (5) an effect of
PCSK9 on adipose tissue biology, (6) an effect of PCSK9 on apolipoprotein B
production from the liver and intestines, (7) an effect of PCSK9 on receptors
other than low density lipoprotein receptor (LDLR) that are involved in TRL
metabolism, and (8) an effect of anti-PCSK9 therapy on serum TG levels. The
underlying mechanisms are unclear but starting to emerge.
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