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2016 ; 1
(ä): 13-22
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PATHOBIOLOGY OF NEURODEGENERATION: THE ROLE FOR ASTROGLIA
#MMPMID27308639
Verkhratsky A
; Zorec R
; Rodriguez JJ
; Parpura V
Opera Med Physiol
2016[Jan]; 1
(ä): 13-22
PMID27308639
show ga
The common denominator of neurodegenerative diseases, which mainly affect humans,
is the progressive death of neural cells resulting in neurological and cognitive
deficits. Astroglial cells are the central elements of the homoeostasis, defence
and regeneration of the central nervous system, and their malfunction or
reactivity contribute to the pathophysiology of neurodegenerative diseases.
Pathological remodelling of astroglia in neurodegenerative context is
multifaceted. Both astroglial atrophy with a loss of function and astroglial
reactivity have been identified in virtually all the forms of neurodegenerative
disorders. Astroglia may represent a novel target for therapeutic strategies
aimed at preventing and possibly curing neurodegenerative diseases.