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suck abstract from ncbi


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pmid27308639
      Opera+Med+Physiol 2016 ; 1 (ä): 13-22
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  • PATHOBIOLOGY OF NEURODEGENERATION: THE ROLE FOR ASTROGLIA #MMPMID27308639
  • Verkhratsky A ; Zorec R ; Rodriguez JJ ; Parpura V
  • Opera Med Physiol 2016[Jan]; 1 (ä): 13-22 PMID27308639 show ga
  • The common denominator of neurodegenerative diseases, which mainly affect humans, is the progressive death of neural cells resulting in neurological and cognitive deficits. Astroglial cells are the central elements of the homoeostasis, defence and regeneration of the central nervous system, and their malfunction or reactivity contribute to the pathophysiology of neurodegenerative diseases. Pathological remodelling of astroglia in neurodegenerative context is multifaceted. Both astroglial atrophy with a loss of function and astroglial reactivity have been identified in virtually all the forms of neurodegenerative disorders. Astroglia may represent a novel target for therapeutic strategies aimed at preventing and possibly curing neurodegenerative diseases.
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