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10.3389/fphys.2015.00093 http://scihub22266oqcxt.onion/10.3389/fphys.2015.00093 C4387954!4387954 !25904867     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25904867 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Physiol 2015 ; 6 (ä): 93 Nephropedia Template TP {{tp|p=25904867 |t=2015. Oxidative stress-mediated HMGB1 biology |pdf=|usr=}}{{25904867 }} gab.com Text Oxidative stress-mediated HMGB1 biology JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25904867 #FOAvip High mobility group box 1 (HMGB1) is a widely-expressed and highly-abundant protein that acts as an extracellular signal upon active secretion by immune cells or passive release by dead, dying, and injured cells. Both intracellular and extracellular HMGB1 play pivotal roles in regulation of the cellular response to stress. Targeting the translocation, release, and activity of HMGB1 can limit inflammation and reduce tissue damage during infection and sterile inflammation. Although the mechanisms contributing to HMGB1 biology are still under investigation, it appears that oxidative stress is a central regulator of HMGB1's translocation, release, and activity in inflammation and cell death (e.g., necrosis, apoptosis, autophagic cell death, pyroptosis, and NETosis). Thus, targeting HMGB1 with antioxidant compounds may be an attractive therapeutic strategy for inflammation-associated diseases such as sepsis, ischemia and reperfusion injury, arthritis, diabetes, and cancer. Twit Text FOAVip Oxidative stress-mediated HMGB1 biology ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25904867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25904867 #FOAvip English Wikipedia <ref>{{Cite pmid|25904867 }}</ref> Oxidative stress-mediated HMGB1 biology #MMPMID25904867 Yu Y ; Tang D ; Kang R Front Physiol 2015[]; 6 (ä): 93 PMID25904867 show ga High mobility group box 1 (HMGB1) is a widely-expressed and highly-abundant protein that acts as an extracellular signal upon active secretion by immune cells or passive release by dead, dying, and injured cells. Both intracellular and extracellular HMGB1 play pivotal roles in regulation of the cellular response to stress. Targeting the translocation, release, and activity of HMGB1 can limit inflammation and reduce tissue damage during infection and sterile inflammation. Although the mechanisms contributing to HMGB1 biology are still under investigation, it appears that oxidative stress is a central regulator of HMGB1's translocation, release, and activity in inflammation and cell death (e.g., necrosis, apoptosis, autophagic cell death, pyroptosis, and NETosis). Thus, targeting HMGB1 with antioxidant compounds may be an attractive therapeutic strategy for inflammation-associated diseases such as sepsis, ischemia and reperfusion injury, arthritis, diabetes, and cancer. äOxidative stress-mediated HMGB1 biology (epmc).pdf DeepDyve Pubget Overpricing