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10.1194/jlr.R066597 http://scihub22266oqcxt.onion/10.1194/jlr.R066597 C5087875!5087875 !27009116     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27009116 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Lipid+Res 2016 ; 57 (11 ): 1976-1986 Nephropedia Template TP {{tp|p=27009116 |t=2016. Oxidative stress and lipotoxicity |pdf=|usr=}}{{27009116 }} gab.com Text Oxidative stress and lipotoxicity JO: J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=27009116 #FOAvip The ?,? polyunsaturated lipid aldehydes are potent lipid electrophiles that covalently modify lipids, proteins, and nucleic acids. Recent work highlights the critical role these lipids play under both physiological and pathological conditions. Protein carbonylation resulting from nucleophilic attack of lysine, histidine, and cysteine residues is a major outcome of oxidative stress and functions as a redox-sensitive signaling mechanism with roles in autophagy, cell proliferation, transcriptional control, and apoptosis. In addition, protein carbonylation is implicated as an initiating factor in mitochondrial dysfunction and endoplasmic reticulum stress, providing a mechanistic connection between oxidative stress and metabolic disease. In this review, we discuss the generation and metabolism of reactive lipid aldehydes, as well as their signaling roles. Twit Text FOAVip Oxidative stress and lipotoxicity ????J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=27009116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27009116 #FOAvip English Wikipedia <ref>{{Cite pmid|27009116 }}</ref> Oxidative stress and lipotoxicity #MMPMID27009116 Hauck AK ; Bernlohr DA J Lipid Res 2016[Nov]; 57 (11 ): 1976-1986 PMID27009116 show ga The ?,? polyunsaturated lipid aldehydes are potent lipid electrophiles that covalently modify lipids, proteins, and nucleic acids. Recent work highlights the critical role these lipids play under both physiological and pathological conditions. Protein carbonylation resulting from nucleophilic attack of lysine, histidine, and cysteine residues is a major outcome of oxidative stress and functions as a redox-sensitive signaling mechanism with roles in autophagy, cell proliferation, transcriptional control, and apoptosis. In addition, protein carbonylation is implicated as an initiating factor in mitochondrial dysfunction and endoplasmic reticulum stress, providing a mechanistic connection between oxidative stress and metabolic disease. In this review, we discuss the generation and metabolism of reactive lipid aldehydes, as well as their signaling roles. |Aldehydes/metabolism [MESH] |Animals [MESH] |Antioxidants/*metabolism [MESH] |Endoplasmic Reticulum Stress/genetics [MESH] |Humans [MESH] |Lipid Metabolism/*genetics [MESH] |Lipid Peroxidation/genetics [MESH] |Oxidative Stress/*genetics [MESH] |Protein Carbonylation/genetics [MESH] |Proteins/*metabolism [MESH] |Reactive Oxygen Species/metabolism [MESH]Oxidative stress and lipotoxicity (epmc).pdf DeepDyve Pubget Overpricing