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10.1002/cphy.c160033 http://scihub22266oqcxt.onion/10.1002/cphy.c160033 C5890934!5890934 !28640448     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28640448 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Compr+Physiol 2017 ; 7 (3 ): 891-944 Nephropedia Template TP {{tp|p=28640448 |t=2017. Overview of the Muscle Cytoskeleton |pdf=|usr=}}{{28640448 }} gab.com Text Overview of the Muscle Cytoskeleton JO: Compr Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28640448 #FOAvip Cardiac and skeletal striated muscles are intricately designed machines responsible for muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the complex cytoskeletal networks are critical for contractile activity. The sarcomere is comprised of precisely organized individual filament systems that include thin (actin), thick (myosin), titin, and nebulin. Connecting the sarcomere to other organelles (e.g., mitochondria and nucleus) and serving as the scaffold to maintain cellular integrity are the intermediate filaments. The costamere, on the other hand, tethers the sarcomere to the cell membrane. Unique structures like the intercalated disc in cardiac muscle and the myotendinous junction in skeletal muscle help synchronize and transmit force. Intense investigation has been done on many of the proteins that make up these cytoskeletal assemblies. Yet the details of their function and how they interconnect have just started to be elucidated. A vast number of human myopathies are contributed to mutations in muscle proteins; thus understanding their basic function provides a mechanistic understanding of muscle disorders. In this review, we highlight the components of striated muscle with respect to their interactions, signaling pathways, functions, and connections to disease. © 2017 American Physiological Society. Compr Physiol 7:891-944, 2017. Twit Text FOAVip Overview of the Muscle Cytoskeleton ????Compr Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28640448 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28640448 #FOAvip English Wikipedia <ref>{{Cite pmid|28640448 }}</ref> Overview of the Muscle Cytoskeleton #MMPMID28640448 Henderson CA ; Gomez CG ; Novak SM ; Mi-Mi L ; Gregorio CC Compr Physiol 2017[Jun]; 7 (3 ): 891-944 PMID28640448 show ga Cardiac and skeletal striated muscles are intricately designed machines responsible for muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the complex cytoskeletal networks are critical for contractile activity. The sarcomere is comprised of precisely organized individual filament systems that include thin (actin), thick (myosin), titin, and nebulin. Connecting the sarcomere to other organelles (e.g., mitochondria and nucleus) and serving as the scaffold to maintain cellular integrity are the intermediate filaments. The costamere, on the other hand, tethers the sarcomere to the cell membrane. Unique structures like the intercalated disc in cardiac muscle and the myotendinous junction in skeletal muscle help synchronize and transmit force. Intense investigation has been done on many of the proteins that make up these cytoskeletal assemblies. Yet the details of their function and how they interconnect have just started to be elucidated. A vast number of human myopathies are contributed to mutations in muscle proteins; thus understanding their basic function provides a mechanistic understanding of muscle disorders. In this review, we highlight the components of striated muscle with respect to their interactions, signaling pathways, functions, and connections to disease. © 2017 American Physiological Society. Compr Physiol 7:891-944, 2017. |Actins/metabolism [MESH] |Animals [MESH] |Cytoskeleton/*metabolism/physiology [MESH] |Humans [MESH] |Muscle Contraction [MESH] |Myosins/metabolism [MESH]Overview of the Muscle Cytoskeleton (epmc).pdf DeepDyve Pubget Overpricing