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Overview of mouse models of autism spectrum disorders
#MMPMID25181011
Bey AL
; Jiang YH
Curr Protoc Pharmacol
2014[Sep]; 66
(?): 5.66.1-5.66.26
PMID25181011
show ga
This overview describes many well characterized mouse models of autism spectrum
disorders (ASDs). Mouse models considered here were selected because they are
examples of genetically engineered models where human genetic evidence supports a
causative relationship between the targeted mutation and the behavioral
phenotype. As the ASD diagnosis is based primarily on behavioral evaluations in
humans in the domains of social interaction, communication, and restricted
interests, the murine phenotypes analogous to human autistic behaviors are
highlighted for the different models and behaviors. Although genetically
engineered mouse models with good construct and face validity are valuable for
identifying and defining underlying pathophysiological mechanisms and for
developing potential therapeutic interventions for the human condition, the
translational value of various rodent behavioral assays remains a subject of
debate. Significant challenges associated with modeling ASDs in rodents because
of the clinical and molecular heterogeneity that characterize this disorder are
also considered.
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